Learn about BYDUREON, a non-insulin treatment option for adults with type 2 diabetes available in the BYDUREON Pen. Find dosing and administration information for BYDUREON, including instructions for use. Learn about BYDUREON® BCise® including efficacy, safety, PK profile, and dosing, and available resources, including Important Safety Information.

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A reduction in the dose of a sulfonylurea may be needed to reduce the risk of hypoglycemia. A reduction in dose of oral hypoglycemic medications may be required in some patients taking orlistat. This is followed by a gradual release of exenatide from the microspheres and a second peak around week 6 to 7. Limited data with exenatide in pregnant women are not sufficient to determine a drug-associated risk for major birth defects or miscarriage.

Octreotide alters the balance between the counter-regulatory hormones of insulin, glucagon, and growth hormone, which may result in hypoglycemia or hyperglycemia. Moderate Niacin nicotinic acid interferes with glucose metabolism and can result in hyperglycemia. Patients on antidiabetic agents should be monitored for the need for dosage adjustments during the use of pentamidine.

Concurrent treatment with prandial insulin has not been studied and cannot be recommended. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Administer at any time of day, with or without meals.


Adjust treatment with antidiabetic agents as clinically indicated. Unlock the autoinjector by turning the knob from lock to unlock until a click is heard. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. For Lixisenatide, the manufacturer recommends taking the OC 1 hour before injection or 11 hours after injection to reduce the effect on absorption. Moderate Pentoxiphylline has been used concurrently with antidiabetic agents without observed problems, but it may enhance the hypoglycemic action of antidiabetic agents.

Moderate Patients receiving antidiabetic agents should use dietary supplements of Garlic, Allium sativum with caution. Constituents in garlic might have some antidiabetic activity, and may increase serum insulin levels and increase glycogen storage in the liver. May be used as monotherapy or with other antidiabetic medications.

Bydureon (exenatide) dose, indications, adverse effects, interactions from

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may decrease antidiabetic agent dosage requirements.

Do not administer by intravenous or intramuscular injection. If a patient chooses to ingest alcohol, they should monitor their blood glucose frequently.

It is not known whether monitoring serum calcitonin or performing thyroid ultrasounds will diminish human risk of thyroid C-cell tumors. Hold the autoinjector upright with the orange cap toward the ceiling.


Exenatide is given via subcutaneous administration. Combined use with prandial insulin has not been studied and cannot be recommended. Hypoglycemia has occurred during fluoxetine therapy.

The agencies have not reached any new conclusions about safety risks of the incretin mimetics, although the totality of the reviewed data provides reassurance.

According to OBRA, the use of antidiabetic medications should include monitoring e. Monitor blood glucose more carefully during initiation or discontinuation of hormone replacement or hormonal contraceptive treatment.

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Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. Moderate Monitor patients receiving octreotide concomitantly with ihsert or other antidiabetic agents for changes in glycemic control and adjust doses of these medications accordingly. Patients receiving these drugs concomitantly should be monitored for changes in glycemic control. Moderate Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Exenatide has been studied in patients 65 years of age or older during clinical trials; safety and pqckage were not different in older adult patients versus younger adult patients.

Exenatide must be well-suspended mixed prior to use from a pen or syringe kit.