Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. Freiberger JJ(1). Author information: (1)Center for Hyperbaric. The benefit of hyperbaric oxygen therapy for osteonecrosis of the femoral head is not proven. IQWiG publishes final report / Therapy should be applied only. Bisphosphonate-Related Osteonecrosis of the Jaw in Cancer Patients and Hyperbaric Oxygen Therapy, Mustafa Erkan, Oguz Bilgi, Mesut Mutluoglu, Gunalp.

Author: Bragrel Faeran
Country: Nigeria
Language: English (Spanish)
Genre: Life
Published (Last): 24 February 2011
Pages: 10
PDF File Size: 2.36 Mb
ePub File Size: 17.97 Mb
ISBN: 405-8-55177-423-7
Downloads: 54671
Price: Free* [*Free Regsitration Required]
Uploader: Samulabar

This is alleged to increase the oxygen supply to the body tissue and stop necrosis. Bisphosphonates are potent inhibitors of osteoclastic bone resorption and one of the most frequently prescribed drugs.

The benefit of hyperbaric oxygen therapy for osteonecrosis of the femoral head is not proven

As the comments produced no queries that needed to be discussed, IQWiG dispensed with an oral scientific debate. In the advanced stage of disease, the femoral head can collapse, so that the htperbaric joint needs to be either surgically stabilised or replaced by a prosthesis.

As to the greater recognition of the relationship between the use of bisphosphonates and oral osteonecrosis, new cases with different malignancies have been diagnosed as suffering from BRONJ. The cumulative incidence of the disease has been reported to be between 0.

Overall, we believe that a multidisciplinary approach is fundamental for achieving a favorable outcome in patients with BRONJ. Although early results are encouraging, evidence-based conclusions could be made after the final results of these studies are published [ 12 ]. Hyperbaric oxygen therapy has been ostepnecrosis in the treatment and prevention of osteoradionecrosis of the jaw for more than 30 years [ 7 ].


A number of papers have been published which describe the successful use of hyperbaric oxygen therapy in the management of BRONJ [ 891011 ]. Hyperbaric oxygen therapy is a way of treatment which increases the oxygen content of the blood and, consequently, the amount of oxygen delivered to tissues.

The final report was sent to the contracting agency, the German Ostronecrosis Joint Committee, on 8 August Hyperbaric oxygen and the cancer patient: Pamidronate Aredia and zoledronate Zometa induced avascular necrosis of the jaws: Objections referring to the content of the preliminary report are discussed in the final report see pages and are fully presented in a separate document. Hyperbbaric are two ongoing randomized controlled trials which are testing the effectiveness of adjunctive hyperbaric oxygen therapy in the management of BRONJ [ 12 ].

The case presented by Smith et al. Systemic antibiotics, an oral antimicrobial rinse and close follow-up are recommended for patients with asymptomatic oral lesions [ 3 ]. The difficulty in the treatment of patients with BRONJ is that surgical approaches such as extensive debridement of the necrotic tissue, and covering the exposed bone with soft tissue flaps often fails and leads to additional exposed bone [ 236 ].

As with carbonic acid in an unopened carbonated water bottle, due to the increase in pressure more oxygen dissolves into the blood plasma.

Bisphosphonate-Related Osteonecrosis of the Jaw in Cancer Patients and Hyperbaric Oxygen Therapy

Although this type of therapy has been tested for about 20 years, data only on about to patients have been published worldwide. Use of platelet-rich plasma in the management of oral biphosphonate-associated osteonecrosis of the jaw: Visit for more related articles at Ostenecrosis.


American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws.

Int J Hematol ; osteomecrosis 4: Comments could be submitted on this version up to 23 May A review of bisphosphonate-associated osteonecrosis of the jaws and its management. The only available comparative study that investigated the research question of this report could not be included in the evaluation because of deficits in methodology and content.

J Oral MaxillofacSurg ; 65 7: After the paper by Marx et al. Oral and intravenous bisphosphonate-induced osteonecrosis of the jaws.

Hyperbaric oxygen therapy and osteonecrosis.

By increasing the ambient pressure, the amount of oxygen in the blood can be substantially increased. However, Feldmeierr et al.

We want to make additional comments on the treatment of patients with BRONJ and, particularly, on the potential role of hyperbaric oxygen therapy in these patients. Quintessence Publishing Co Inc; The cause of the idiopathic form of disease is hylerbaric, unlike the cause of secondary or traumatic osteonecrosis of the femoral head.

However, the comments submitted were considered.