IDIOPATIK TROMBOSITOPENIA PURPURA ADALAH PDF
Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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IDIOPATIK TROMBOSITOPENIA PURPURA PDF
Management of immune thrombocytopenic purpura in pregnancy. Signs of chronic disease, infection, wasting, or poor nutrition indicate that the patient has another illness. Immune thrombocytopenic purpura ITP.
The acute form often follows an infection and has a spontaneous resolution within two months. Views Read Edit View history. The mechanism of action of anti-D is not fully understood. The dose and mode of administration is determined by platelet count and whether there is active bleeding: All medications for ITP are given either orally or IV; intramuscular injection is avoided due to the possibility of causing bleeding into the skin.
This website also contains material copyrighted by 3rd parties. Once the platelet count has improved, the dose of steroid is gradually reduced adalan the possibility of relapse is monitored.
General care includes explaining ITP to the patient and advising him or her to watch for bruising, petechiae, or other signs of recurrence. To date, the diagnosis of ITP is still arrived at by tromhositopenia, i.
N Engl J Med ; Chronic idiopathic thrombocytopenic purpura. Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. Then, secondary causes 5—10 percent of suspected ITP cases should be excluded. Archived from the original on It is a thrombopoiesis stimulating Fc-peptide fusion protein peptibody. Chronic idiopathic thrombocytopenic purpura: The incidence of ITP is estimated at 50— new cases per million per year, with children accounting for half of that amount.
We present a case report on ITP with clinical presentation, diagnosis and management. Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus. Some children may need treatment. Platelet transfusion is not normally recommended and is usually unsuccessful in raising a patient’s platelet count. Patient started treatment 7 years back and was on tablet isosorbide dinitrate 10 mg, tablet atenelol 25 mg, tablet envas 5 mg and patient had discontinued aspirin 6 months back.
Sekhon SS, Roy V. The Netherlands Journal of Medicine. Ninety-six percent of reported ITP-related deaths were individuals 45 years or older.
Idiopathic thrombocytopenic purpura
ABC of clinical haematology. This article has been cited by other articles in PMC. In mild cases, only careful observation may be required but very low counts or significant bleeding may prompt treatment with corticosteroidsintravenous immunoglobulinanti-D immunoglobulinor immunosuppressive medications.
Transfusion-associated graft versus host disease. Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. The bleeding manifestations of thrombocytopenia are described as mucocutaneous to distinguish them from coagulation disorders like hemophilia.
Hematol Oncol Clin North Am. The spleen is tronbositopenia site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp. Pediatr Rev ; This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.
In chronic refractory cases, where immune pathogenesis has been confirmed,  the off-label use of the vinca alkaloid    and trombositopeni agent vincristine may be attempted.
Older patients have more severe and rare bleeding manifestations, such as GI bleeding and possibly intracranial hemorrhage secondary to co-morbidities such as hypertension. Bleeding time is usually prolonged in ITP patients. Am Soc Hematol ;— ITP symptoms can include any of the following: It causes a characteristic purpuric rash and an increased tendency to bleed. Goldman L, Schafer AI, eds. Petechia of the lower leg in a person with platelets of 3 due to ITP.